Regulating the ribosome

The goal of our research is to understand at a molecular level how the ribosome and protein synthesis are regulated in the cell. This is achieved by using a combination of biochemical and structural analysis using X-ray crystallography and cryo-electron microscopy.

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Current projects in the laboratory are related to the following specific topics:

1. Regulation of translation by nascent polypeptide mediated stalling.
2. Translation response to environmental stress
3. Factor mediated regulation of ribosome biogenesis
4. Antibiotic inhibition of the ribosome