Regulation of Gene Expression: The Ribosome and Protein Synthesis

In every living organism, translation of the genetic code into functional proteins is performed on the ribosome. Indeed, the fundamental importance of translation is reflected by the fact that the ribosome is a major target in the cell for natural antibiotics. The Wilson lab takes a combined structure-function approach to address how specific ligands, such as antibiotics as well as protein factors, modulate gene expression via interaction with the translational apparatus.